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Our Pipeline
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Our Pipeline

A growing pipeline of T-SIGn® therapeutics aiming to enable a patient’s immune system to recognize, attack, and clear solid tumors.

Akamis Bio has a growing pipeline of T-SIGn® therapeutics capable of driving the intratumoral expression of a broad range of therapeutic proteins, as well as immunologically active biomolecules which aim to enable a patient’s immune system to recognize, attack, and clear solid tumors.

 

With more than 200 patients treated across our clinical studies, T-SIGn® therapeutics have demonstrated a consistent safety & tolerability profile, as well as promising preliminary evidence of clinical activity.

Stage

NG-347

Three transgenes:

producing membrane bound CD80 and secreted MIP1α and IFNα

T-cell attraction

and activation

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NG-796A

Three transgenes:

producing IL-12, IL-15 and a chemokine

T-cell and

NK Cell 

activation

NG-XXX

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Novel transgene combinations

Variety of mechanisms targeted

Product

Transgene

Payload

Principal

Mechanism

NG-350A

Two transgenes:

producing a secreted CD40 agonist monoclonal antibody

NG-641

Four transgenes:

producing an anti-FAP bispecific plus cytokines/ chemokines

CD40 Agonism

Phase 1

Phase 2

Phase 3

Research

IND

Enabling

Commercial Rights

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Anti-

Stromal

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Akamis Bio 2 Transgene
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Akamis Bio 4 Transgene
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Akamis Bio Three Transgene
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Akamis Bio Three transgenes
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Akamis Bio 2 Transgene

NG-348

Two transgenes:

producing membrane bound anti-CD3 scFv antibody and CD80

Immune cell recruitment & activation

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